Can [18F]FOL PET imaging detect activated macrophages and predict left ventricular systolic function worsening in experimental myocardial infarction?
[18F]FOL PET imaging can successfully detect activated macrophages post-MI, with early FR-β expression predicting worsening left ventricular systolic function.
18FFOL PET detects expression of FR-β, a marker of activated macrophages after MI. FR-β expression peaks early and remains elevated up to 3 months post-MI. Early FR-β expression is associated with worsening of left ventricular systolic function.
Iqbal et al. (Sun,) studied this question.
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