Network pharmacology-guided elucidation of metformin and irinotecan mechanisms in 2D and 3D cancer cell models

Key Points

• Metformin and irinotecan demonstrate distinct mechanisms in 2D and 3D cancer cell models, highlighting their potential synergy.
• Key findings reveal that metformin enhances the effects of irinotecan, impacting cancer cell growth and survival rates.
• Analysis focuses on the molecular pathways influenced by metformin and irinotecan in different cancer environments.
• Further investigation is needed to validate these findings across diverse cancer types and models.