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Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality | Synapse
March 3, 2026
Open Access
Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality
CE
Cristian Estarellas
EÁ
Efrén Álvarez-Salvado
LP
Laura Pérez-Cervera
Instituto de Neurociencias
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Key Points
Enhanced functionality in the dentate gyrus is linked to inhibitory reorganization, providing insights into brain adaptability.
Key evidence shows significant improvements in dentate gyrus performance through altered inhibitory dynamics.
This analysis employs observational methods to explore the impact of synaptic plasticity on inhibitory networks.
Understanding these mechanisms may open avenues for therapeutic strategies targeting cognitive enhancement.
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Estarellas et al. (Tue,) studied this question.
synapsesocial.com/papers/69a76613badf0bb9e87db8f0
https://doi.org/https://doi.org/10.1016/j.isci.2026.114878
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