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March 3, 2026
Chemogenetic modulation of CNS pericytes: Impact on pericyte Ca2+ dynamics, CBF, BBB, and Alzheimer’s disease progression in mice
YW
Yan Wu
Nanjing Tech University
PL
Pengfei Li
Medical University of South Carolina
LL
Liu Liu
Medical University of South Carolina
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Key Points
Altered calcium dynamics lead to significant changes in cerebral blood flow during Alzheimer's disease progression.
In vivo assessment showed a 40% increase in pericyte Ca2+ levels, impacting blood-brain barrier integrity.
Chemogenetic modulation of CNS pericytes was employed to evaluate changes in blood flow metrics in live mice.
Findings indicate disruptions in calcium signaling may contribute to Alzheimer's disease effects on brain health.
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Chemogenetic modulation of CNS pericytes: Impact on pericyte Ca2+ dynamics, CBF, BBB, and Alzheimer’s disease progression in mice | Synapse
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Wu et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76621badf0bb9e87dbd00
https://doi.org/https://doi.org/10.1016/j.ymthe.2026.01.040