An ultrasound-activated PROTAC prodrug with self-reporting fluorescence for targeted protein degradation

Key Points

• Targeted protein degradation was achieved through a novel ultrasound-activated prodrug system.
• The self-reporting fluorescence showed distinct patterns in protein dynamics, enabling precise monitoring.
• Analysis revealed substantial degradation efficacy, suggesting improved therapeutic targets in disease management.
• The approach may enable enhanced specificity in treating conditions through targeted molecular interventions.