Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics

Key Points

• The findings indicate that tgf-β1-smad/mapk signaling is a pathway of genetic susceptibility to pm2.5 exposure in pediatric asthma.
• Key evidence includes the identification of this signaling axis as a plausible mechanism influencing asthma responses to pm2.5.
• Integrative genomic and transcriptomic analyses were performed to explore transcriptional responses in pediatric asthma.
• These results underscore the need for functional validation to confirm these hypotheses on pm2.5 exposure.