Genipin-crosslinked biopolymer hydrogels for controlled quercetin delivery: Antibacterial activity, cytocompatibility and docking-assisted protein interaction

Key Points

• Quercetin delivery using genipin-crosslinked biopolymer hydrogels shows significant antibacterial activity, enhancing treatment options.
• The study reports effective quercetin release with approximately 75% bioavailability, highlighting the biopolymer's potential.
• Assessment employs docking-assisted interaction studies to explore protein engagement with quercetin, indicating possible mechanisms.
• Cytocompatibility emphasizes safe usage in biological systems, suggesting a promising path for medicinal applications.