Bifidobacterium pseudocatenulatum AL44 ameliorates Enterococcus faecium-induced lung inflammation through NLRP3 suppression along the gut-lung axis

Key Points

• Lung inflammation was significantly reduced when treated with bifidobacterium pseudocatenulatum AL44, impacting the gut-lung axis.
• NLRP3 suppression was identified as a key mechanism, revealing the interplay between gut microbiota and inflammation.
• The assessment used a model of enterococcus faecium-induced lung inflammation to determine effectiveness of the intervention.
• These findings highlight the potential of targeting gut bacteria for alleviating respiratory inflammation and may lead to novel therapies.