March 3, 2026Open Access

Analysis of the association between SLCO1B1 gene polymorphisms and coronary heart disease risk in southern Han Chinese population and statin responses in the elderly

Key Points

The SLCO1B1 c.521C allele is linked to higher coronary heart disease risk in southern Han Chinese.
Standard-dose statin therapy remains effective and safe for elderly individuals carrying the SLCO1B1 c.521T>C polymorphism.
Analysis indicates that genetic screening can assist in preventing cardiovascular diseases in older adults.
Findings emphasize the role of individual genetic profiles in optimizing statin-based lipid-lowering strategies.

Abstract

The SLCO1B1 c.521C allele represents an independent genetic marker for CHD susceptibility in the southern Han Chinese population. In geriatric populations, standard-dose statin therapy maintains lipid-lowering efficacy and safety, unaffected by the SLCO1B1 c.521T>C polymorphism. Our findings provide a genetic screening tool for the primary prevention of cardiovascular diseases and offer support for the efficacy and safety of statin-based lipid-lowering therapy in adults aged >75 years.

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Cite This Study

Long et al. (Fri,) studied this question.

synapsesocial.com/papers/69a766f6badf0bb9e87df1b8 https://doi.org/https://doi.org/10.3389/fcvm.2026.1645446

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