Genetic association of miR-146a, miR-196a2, and miR-499 polymorphisms with hepatocellular carcinoma risk in an Eastern Chinese population

Key Points

• miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms are significantly linked to hepatocellular carcinoma susceptibility.
• The analysis identified miR-196a2 and miR-499 as promising genetic biomarkers for early risk assessment in eastern Chinese individuals.
• A comprehensive genetic association study demonstrated notable susceptibility patterns for specific polymorphisms in HCC cases.
• These findings may enable targeted early detection strategies, potentially leading to better outcomes for at-risk individuals.