Camellia japonica hyperoside exhibits anti-age-related macular degeneration effects in an ARPE-19 cell model by inhibiting apoptosis via JNK-Nrf2/HO-1 activation | Synapse
March 3, 2026Open Access
Camellia japonica hyperoside exhibits anti-age-related macular degeneration effects in an ARPE-19 cell model by inhibiting apoptosis via JNK-Nrf2/HO-1 activation
Key Points
C. japonica hyperoside inhibits apoptosis to reduce age-related macular degeneration.
The treatment led to significant activation of JNK-Nrf2/HO-1 pathways in ARPE-19 cells.
Assessment using an ARPE-19 cell model demonstrated potential therapeutic benefits over time.
This discovery calls for further investigation into hyperoside's utility as an AMD treatment.
Abstract
We conclude that C. japonica hyperoside could be a promising anti-AMD drug.