Evaluation of natural compounds as potent thymidine phosphorylase inhibitors: In Vitro, molecular docking and density functional theory analysis | Synapse
March 3, 2026
Evaluation of natural compounds as potent thymidine phosphorylase inhibitors: In Vitro, molecular docking and density functional theory analysis
Key Points
Thymidine phosphorylase inhibition showed significant results using various natural compounds, demonstrating potential for drug development.
Key evidence revealed that certain compounds reduced enzymatic activity by over 70%, indicating effectiveness in inhibition.
This analysis utilized molecular docking and density functional theory to assess the binding affinity and interaction of compounds with the enzyme.
These findings highlight the potential for developing natural compound-based therapies, though further clinical exploration is needed.