Mitigation of dose-dependent cilostazol absorption from cocrystals: A coformer regulates gastric dissolution and absorption profiles

Key Points

• Cilostazol absorption is significantly affected by the formulation's gastric dissolution properties—dose-dependent effects were observed.
• Key evidence includes a marked increase in absorption efficiency at varying doses of cilostazol with the chosen cocrystals.
• Assessment used cocrystal formulations to analyze absorption profiles relative to typical dissolution standards.
• Significance lies in the potential for improved drug delivery and efficacy, suggesting practical applications in pharmaceutical formulations.