Protective effect of resveratrol against colistin-induced nephrotoxicity through regulating Nrf2 pathway and inhibiting ferroptosis

Key Points

• Resveratrol effectively reduces nephrotoxicity caused by colistin treatment, highlighting its protective properties.
• Colistin administration leads to increased markers of nephrotoxicity, with significant reductions observed when resveratrol is included in the treatment regimen.
• This analysis focuses on regulating the nrf2 pathway and inhibiting ferroptosis as potential mechanisms of action for resveratrol.
• Understanding these mechanisms may provide avenues for therapeutic strategies against antibiotic-induced kidney damage.