Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model

Key Points

• Altered segmental outflow is linked to IOP elevation in young ocular hypertensive mice, indicating key mechanical changes.
• Dexamethasone treatment influences flow distribution, impacting trabecular meshwork stiffness rather than extracellular matrix properties.
• Analysis of segmental flow and trabecular meshwork mechanics reveals potential mechanisms behind steroid-induced glaucoma in this mouse model.
• These findings suggest the importance of understanding trabecular meshwork behavior for developing future glaucoma therapies.