LASP1 mediates ADAM17 upregulation in high glucose to promote fibrosis in diabetic kidneys

Key Points

• Fibrosis occurs in diabetic kidneys due to upregulation of ADAM17 mediated by LASP1, contributing to kidney damage.
• High glucose conditions led to increased LASP1 levels, which directly correlated with ADAM17 activity.
• Using in vitro models, the study assessed the interaction of LASP1 with ADAM17 and its impact on fibrosis.
• Implications point to LASP1 as a promising target for treatments aimed at mitigating diabetic kidney disease.