Global distribution and genomic architectures of plasmid-mediated quinolone resistance genes in Shigella from 1998 to 2025

Key Points

• Plasmid-mediated quinolone resistance genes are widespread across various regions globally, impacting treatment options.
• Key evidence reveals significant genomic diversity among Shigella strains, highlighting the complex nature of resistance mechanisms.
• Assessment of resistance genes uses genomic analysis of Shigella samples collected from 1998 to 2025, tracking temporal changes.
• These findings underscore the urgent need for global surveillance and intervention strategies to combat antibiotic resistance.