A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition.

Key Points

• The review aims to evaluate the effects of semaglutide on visceral adipose tissue (VAT) and cognitive functioning.
• Conducted a systematic review of available studies on semaglutide effects.
• Performed a meta-analysis on the data collected from original investigations.
• Analyzed the heterogeneity among studies to determine consistency of findings.
• Found that semaglutide is associated with significant VAT loss.
• Observations suggest potential benefits for cognitive preservation.
• Noted high variability in the results, indicating further research is needed.