tDCS effects on life engagement in schizophrenia: results from a double-blind sham-controlled trial. | Synapse
March 4, 2026
tDCS effects on life engagement in schizophrenia: results from a double-blind sham-controlled trial.
Key Points
To investigate the effects of prefrontal tDCS on life engagement in individuals with schizophrenia.
Double-blind sham-controlled trial design
Application of transcranial direct current stimulation (tDCS) to the prefrontal cortex
Integration of patient-reported outcome measures (PROMs) to assess life engagement
tDCS demonstrated a positive effect on life engagement compared to sham stimulation
Improvements were evident regardless of core symptom domains present in schizophrenia
Abstract
This study provides preliminary evidence that prefrontal tDCS may enhance LE in schizophrenia, independently of core symptom domains, supporting the integration of PROMs in neuromodulation research.