July 4, 2019

Pathologic T-cell response in ischaemic failing hearts elucidated by T-cell receptor sequencing and phenotypic characterization

Structured PICO

Population

Ischaemic failing human hearts

Outcome

Tissue-specific T-cell responsesurrogate

Identifies a specific T-cell response (Th1 and CD8+) in ischemic failing human hearts that may drive heart failure progression.

Abstract

We provide novel evidence for a tissue-specific T-cell response predominated by Th1 cells and cytotoxic CD8+ T cells in ischaemic failing human hearts that may contribute to the progression of heart failure.

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Cite This Study

Tang et al. (Thu,) studied this question.

synapsesocial.com/papers/69a885cf79e4282fc692872e https://doi.org/https://doi.org/10.1093/eurheartj/ehz516

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