Photo-induced silylation cyclization of indole-tethered 1,6-enynes to access silylated pyrrolo1,2-aindole derivatives

Key Points

• The aim is to explore a method for synthesizing silylated pyrrolo[1,2-a]indoles via photo-induced cyclization.
• Utilized photo-induced silylation of indole-tethered 1,6-enynes.
• Employed tris(trimethylsilyl)silane and silylboronate in the reaction.
• Assessed selectivity and yields of the formed compounds.
• Implemented HH-Noesy spectroscopy and scaled-up operations.
• Successfully synthesized various silylated pyrrolo[1,2-a]indole derivatives.
• Achieved high selectivity and good yields in the cyclization process.
• Confirmed the effectiveness of the method through complex molecular derivatization.