March 7, 2026
Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.
Key Points
- The study aims to explore the protective effects of Grifola frondosa polysaccharide against chronic kidney disease (CKD) induced by adenine in mice.
- Administered Grifola frondosa polysaccharide to mice with adenine-induced CKD.
- Evaluated antioxidant, anti-inflammatory, and anti-fibrotic activities.
- Assessed the involvement of the TGF-β1/Smad signaling pathway.
- Grifola frondosa polysaccharide significantly reduced kidney damage markers.
- Treatment suppressed TGF-β1/Smad signaling pathway activation.
- Demonstrated antioxidant and anti-inflammatory effects in treated mice.
Abstract
Our findings demonstrated that GFP exerted potent renoprotection against adenine-induced CKD in mice, mediated by its antioxidant, anti-inflammatory, and anti-fibrotic activities. The anti-fibrotic mechanism was mediated via the suppression of the TGF-β1/Smad signaling pathway. These results highlighted the potential of GFP as functional food ingredients or adjunctive therapeutic agents for preventing and treating CKD and its complications. © 2026 Society of Chemical Industry.
Shi et al. (Thu,) studied this question.
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