The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents

Key Points

• To investigate the impact of neuroprotectors on BDNF levels, inflammation markers, and apoptosis in acute cerebrovascular accidents.
• Administered Mexidol at reperfusion onset following MCA occlusion.
• Measured levels of BDNF and tumor necrosis factor alpha.
• Assessed markers of apoptosis and neuroinflammation.
• Mexidol significantly increased BDNF levels.
• Reduced tumor necrosis factor alpha and apoptosis markers observed.
• Prominent cerebroprotective effects contributing to neurogenesis noted.