What does this research mean for the field?

Del Nido cardioplegia provides superior myocardial protection and fewer post-cross-clamp ventricular arrhythmias than Custodiol in minimally invasive mitral valve repair, despite comparable overall clinical outcomes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to compare myocardial protection and clinical outcomes between Custodiol and Del Nido cardioplegia during minimally invasive mitral valve repair.

March 7, 2026Open Access

Custodiol versus Del Nido cardioplegia in minimally invasive mitral valve repair–a propensity score-matched study

Key Result

Del Nido cardioplegia showed better myocardial protection and fewer post-cross-clamp ventricular arrhythmias than Custodiol in minimally invasive mitral valve repair.

Key Points

The study aims to compare myocardial protection and clinical outcomes between Custodiol and Del Nido cardioplegia during minimally invasive mitral valve repair.
Conducted a propensity score-matched analysis of patients undergoing minimally invasive mitral valve repair.
Evaluated biomarker dynamics and incidence of post-cross-clamp ventricular arrhythmia between cardioplegic solutions.
Compared overall clinical outcomes between the two cardioplegia methods.
Del Nido cardioplegia showed superior myocardial protection as indicated by biomarker dynamics.
Lower incidence of post-cross-clamp ventricular arrhythmia was observed with Del Nido compared to Custodiol.
Overall clinical outcomes between the two methods remained comparable.

Structured PICO

Does Del Nido cardioplegia improve myocardial protection and reduce arrhythmias compared to Custodiol in patients undergoing minimally invasive mitral valve repair?

Population

Patients undergoing minimally invasive mitral valve repair

Intervention

Del Nido cardioplegia

Comparator

Custodiol cardioplegia

Outcome

Myocardial protection (assessed by biomarker dynamics) and incidence of post-cross-clamp ventricular arrhythmiasurrogate

Del Nido cardioplegia may be the preferred single-dose cardioplegic solution for minimally invasive mitral valve repair due to superior myocardial protection and lower arrhythmia incidence compared to Custodiol.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Del Nido cardioplegia provided superior myocardial protection based on biomarker dynamics and a lower incidence of post-cross-clamp ventricular arrhythmia, while overall clinical outcomes remained comparable. It may therefore be considered the preferred single-dose cardioplegic solution for minimally invasive mitral valve repair.