Design, synthesis, and biological evaluation of X19: a matrine pyrazole derivatives therapeutic candidate | Synapse
March 7, 2026
Design, synthesis, and biological evaluation of X19: a matrine pyrazole derivatives therapeutic candidate
Key Points
To design and synthesize matrine-pyrazole derivatives to improve their effectiveness in treating tumors.
Structural modification of the natural alkaloid matrine
Synthesis of novel compounds
Biological evaluation of antitumor effects
Enhanced antitumor efficacy observed in synthesized derivatives
Demonstrated improved performance compared to the original matrine
Abstract
A series of novel matrine-pyrazole derivatives were designed and synthesized through structural modification of the natural alkaloid matrine to enhance its antitumor efficacy.