The mechanochemical synthesis of 4,5‐dihydro‐1,3‐thiazol‐2‐amines and 1,3‐thiazolidine‐2‐imine hydrochlorides has been performed starting from chloroalkyl isothiocyanate and amines in the presence of potassium carbonate. The proposed procedure is efficient under transition metal‐ and solvent‐free ball‐milling conditions with the use of a mixer mill. The reactions are selective and show no significant decrease in yields across a broad scope of substrates bearing different functional groups. Moreover, the successful 1 g scale‐up experiment demonstrates the practical applicability of the method.
Hanek et al. (Wed,) studied this question.