ABSTRACT Bioelectronics, as a bridge between electronic devices and living systems, is rapidly advancing toward transformative applications in human–machine interfaces and intelligent healthcare. Conjugated polymers (CPs) are driving revolutionary advances in bioelectronics by offering a unique combination of high electronic conductivity and tissue‐compliant mechanical properties. This perspective summarizes recent progress in the application of CPs as conductors or semiconductors in next‐generation implantable bioelectronic devices, highlighting key strategies for enhancing the biocompatibility of CP‐based devices, such as superior tissue–device interfacing, low cytotoxicity, and immune compatibility. We further review their roles in advanced bioelectronic applications, from signal acquisition to sensing, and discuss the key challenges of device integration, long‐term stability, and degradability that must be addressed for clinical translation, and offer an outlook on the future development of CP‐based bioelectronic systems.
Gao et al. (Tue,) studied this question.