Multi-omics analysis reveals Yishen Qutong formula promotes ferroptosis in Lewis lung cancer associated with Keap1/Nrf2/Nqo1 pathway modulation | Synapse
March 12, 2026Open Access
Multi-omics analysis reveals Yishen Qutong formula promotes ferroptosis in Lewis lung cancer associated with Keap1/Nrf2/Nqo1 pathway modulation
Key Points
The aim is to investigate how Yishen Qutong formula induces ferroptosis in Lewis lung cancer through specific molecular pathways.
Conducted multi-omics analysis to assess biochemical interactions.
Evaluated the role of 3-hydroxycinnamic acid as a serum component in YSQTF.
Analyzed the expression modulation of Keap1 using various experimental techniques.
YSQTF significantly promotes ferroptosis in Lewis lung cancer cells.
Alterations in the Keap1/Nrf2/Nqo1 pathway were observed in response to YSQTF treatment.
3-hydroxycinnamic acid contributed to the regulation of Keap1 expression.
Abstract
YSQTF promoted ferroptosis in Lewis lung cancer, which was associated with the Keap1/Nrf2/Nqo1 pathway. 3-hydroxycinnamic acid might be a serum component in YSQTF regulating the the expression of Keap1.