What question did this study set out to answer?

To assess long-term outcomes and toxicity from a risk-adapted treatment strategy for clinical stage I testicular germ-cell tumours.

March 12, 2026Open Access

24P Patient-reported outcomes and long-term toxicity in clinical stage I testicular germ cell tumour survivors treated under a risk-adapted strategy

Key Points

To assess long-term outcomes and toxicity from a risk-adapted treatment strategy for clinical stage I testicular germ-cell tumours.
Retrospective cohort study of patients treated between 1994-2023.
Post-orchiectomy management utilized a risk-adapted approach.
Endpoints included relapse, progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS).
Statistical associations analyzed using Cox and Fisher's exact tests.
Evaluation of the Boormans three-factor model in surveillance-managed seminoma.
Effective long-term survival rates reported with limited chemotherapy exposure.
Relapse and progression rates were assessed alongside overall and cancer-specific survival outcomes.
Boormans model showed potential for accurately identifying risk categories.

Abstract

Background: Clinical stage I (CSI) testicular germ-cell tumours (TGCT) represent a model of highly curable solid malignancy and the key challenge is now to preserve near-universal cure rates while limiting exposure to potentially toxic adjuvant therapy and long-term sequelae.We evaluated long-term outcomes of a risk-adapted strategy designed to limit chemotherapy to clearly defined high-risk subgroups and to prevent overtreatment in low-risk patients.Methods: Retrospective single-centre cohort of CSI TGCT managed between 1994-2023.Post-orchiectomy management followed a risk-adapted policy.Endpoints were relapse, progression-free survival (PFS), overall survival (OS) and CSS.Associations were analysed with Cox and Fisher's exact tests.In surveillance-managed seminoma, the Boormans three-factor model (categorical size, RTI, LVI) was assessed for discrimination and 5-year calibration.

Perguntar à IA

Bookmark

View Full Paper