What question did this study set out to answer?

The aim is to develop a selective method for hydrohydrazidation of alkynes using gold(I) catalysts.

March 12, 2026Organic Chemistry Frontiers0 citations

Ligand-Enabled Hydrohydrazidation of Alkynes Catalyzed by Unsymmetrical Gold(I)-Thiazol-2-ylidenes

SMShidi MaShaanxi University of Science and Technology JZJin ZhangShaanxi University of Science and Technology YZYawei ZhuRutgers, The State University of New Jersey

Key Points

The aim is to develop a selective method for hydrohydrazidation of alkynes using gold(I) catalysts.
Utilized unsymmetrical gold(I)-thiazol-2-ylidene complexes as catalysts.
Performed reactions with various alkynes and acyl hydrazines.
Analyzed selectivity and efficiency of the hydrohydrazidation process.
Achieved high selectivity for the hydrohydrazidation of alkynes.
Demonstrated effectiveness of gold(I)-thiazol-2-ylidene catalysts in organic synthesis.
Reported enhanced yields in the formation of amide derivatives.

Abstract

Acyl hydrazines represent a privileged class of amide derivatives in organic synthesis and drug discovery, however, methods for effecting site-selective hydrohydrazidation remain underdeveloped. Herein, we report highly selective Au(I)-NHC catalyzed...

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