Fibroblast-activation protein inhibitors based positron emission tomography (PET) for assessing lung disease: A systematic review with meta-analysis

Key Points

• The research aims to assess the effectiveness of FAPI PET/CT in diagnosing lung diseases, particularly non-oncological ones.
• Systematic review of existing literature on FAPI PET/CT for lung disease assessment.
• Meta-analysis to evaluate diagnostic performance across studies.
• Inclusion of studies assessing both tumours and non-tumour lesions.
• FAPI PET/CT shows excellent diagnostic performance for identifying lung tumours.
• CT scans often fail to accurately diagnose conditions like IPF, leading to treatment delays.
• Meta-analysis supports FAPI PET's potential in both oncological and non-oncological lung disease assessments.