Sodium Nitroprusside Potentiates Capsaicin‐Activated TRPV1‐mediated Relaxation of Goat Detrusor Smooth Muscle

Key Points

• The aim is to investigate how sodium nitroprusside affects capsaicin-induced relaxation in goat detrusor smooth muscle via TRPV1 channels.
• Examined the expression of TRPV1 channels in goat detrusor smooth muscle (DSM).
• Tested the effects of capsaicin on smooth muscle relaxation.
• Assessed the role of sodium nitroprusside (SNP) in potentiating this relaxation through NO-cGMP signaling.
• Capsaicin was found to effectively induce relaxation in goat DSM.
• Sodium nitroprusside significantly enhanced the relaxation effect of capsaicin.
• The mechanism involves the NO-cGMP signaling pathway, indicating functional TRPV1 channels.