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This review focuses on the need for effective antiviral drug development for COVID-19 and future pandemics.

March 14, 2026

Advancing COVID-19 Therapies: Targeting Key Pathways and Insightsfor Future Pandemics

Key Points

This review focuses on the need for effective antiviral drug development for COVID-19 and future pandemics.
Review of antiviral drugs targeting key viral proteins like S-protein, Mpro, PLpro, and RdRp.
Analysis of existing treatment strategies for COVID-19.
Identification of multiple therapeutic targets for drug development.
Highlights pivotal viral proteins as targets for antiviral drugs.
Emphasizes the necessity for drugs addressing potential future pandemic threats.
Offers insights into ongoing progress in developing treatments for emerging coronaviruses.

Abstract

The COVID-19 pandemic has rapidly spread across global societies, caused by the SARS-CoV-2, leading to significant challenges and impacts. The development of antiviral drugs targeting pivotal viral proteins, particularly the S-protein, Mpro, PLpro, and RdRp, offers a promising strategy for addressing the complexity of treating COVID-19. There is a need to focus on the development of COVID-19 drugs that aim at multiple targets. In particular, developing effective antiviral drugs is essential for addressing potential future pandemic threats. Hence, this review highlights the principal COVID-19 targets and other possible targets, and offers critical insights into the ongoing progress toward developing effective treatments for COVID-19 and other emerging coronaviruses.

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