Chimeric Enediynes as Potent Antivirals against Coronaviruses by Targeting the Conserved Free-Fatty-Acid Binding Site on the Spike Protein

Key Points

• This research aims to explore chimeric enediynes as effective antiviral agents against coronaviruses.
• Developed a targeted protein degradation platform named PROTEC.
• Focused on targeting the spike protein of coronaviruses.
• Utilized protein–radical–oxidation targeting enediyne chimera strategies.
• Identified chimeric enediynes as potent antivirals against coronaviruses.
• Demonstrated reduced viral activity through targeted interaction with the spike protein.