Abstract Introduction: Mechanical ventilation, while life-saving, increases the risk of ventilator-associated pneumonia (VAP), commonly due to colonization of the lower respiratory tract by multidrug-resistant pathogens. Understanding local microbial patterns and resistance profiles is critical for optimizing empirical therapy and improving ICU outcomes. Aims and Objectives · To analyzed the culture profile and antibiogram of infective organisms isolated from endotracheal secretions in mechanically ventilated patients. · To Approval for the study was obtained from the Institutional Ethics Committee, and written informed consent was secured from the patients’ caregivers or legal representatives. Material and Method: Study Design: Cross Sectional Study Study Period: The study was conducted over six months June 2023–November 2023. Study Place: Department of Microbiology, M.P. Shah Government Medical College, Jamnagar, Gujarat. Sample Size: Total sample size 113. Study Population: Patients scheduled for elective microbiology laboratory Sampling Method: Susceptibility Testing Result: In total, 113 samples were processed. tracheal aspirates were 113, with males (47/113) outnumbered females (26/113). Out of a total of 113 samples, 73 (64.40%) were culture-positive and 40 (36.60%) were sterile. Acinetobacter spp. was the most common pathogen among 72 culture positives (27/73, 36.98%), followed by Klebsiella spp. (21/73, 28.50%), Pseudomonas spp. (13/73, 17.80%), and Escherichia coli (8/73, 9.59%) and Staphylococcus aureus (6/73, 8.22%). Conclusion: The study highlights the growing prevalence of multidrug-resistant pathogens in ventilated ICU patients, emphasizing the need for ongoing microbiological surveillance and judicious antimicrobial use to reduce morbidity and mortality.
International Journal of Medical Science and Advanced Clinical Research (IJMACR) (Fri,) studied this question.