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Develop imaging recommendations for high-risk neuroblastoma to enhance care standards.

March 15, 2026Pediatric Blood & Cancer2 citationsOpen Access

Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

ALAnnemieke S. LittooijUtrecht University COCatia OliantiAzienda Ospedaliero-Universitaria Careggi HBHervé J. BrisseUniversité Paris Sciences et Lettres

Key Points

Develop imaging recommendations for high-risk neuroblastoma to enhance care standards.
Consensus-based recommendations from SIOPEN Radiology and Nuclear Medicine Specialty Committees.
Focus on imaging at first presentation and during follow-up of high-risk neuroblastoma.
Aim to improve reproducibility in neuroblastoma imaging.
Enhance diagnostic performance for better treatment outcomes.
Assist in the development of future clinical trials.

Abstract

Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees developed consensus-based imaging recommendations for high-risk neuroblastoma at first presentation and throughout follow-up. These expert opinions aim to improve reproducibility and enhance diagnostic performance in order to advance the current standard of care and assist in the development of future trials.

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