What does this research mean for the field?

The lead compound 5qq exhibits potent antimicrobial activity with a minimum inhibitory concentration (MIC) of 4 µg/mL. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to develop a one-pot synthesis method for indole-embedded dihydropyrazoles using iodine-mediated amination.

March 16, 2026

Iodine-Mediated Cascade Amination Enables One-pot Access to Antimicrobial Indole-Embedded Dihydropyrazoles

Key Points

The study aims to develop a one-pot synthesis method for indole-embedded dihydropyrazoles using iodine-mediated amination.
Utilized a metal-free approach for amination
Conducted a one-pot synthesis process
Tested antimicrobial activity of synthesized compounds
Lead compound 5qq showed potent antimicrobial activity with an MIC of 4 µg/mL
The synthesis method has a broad substrate scope

Abstract

A metal-free, iodine-mediated amination enables a one-pot synthesis of indole-embedded dihydropyrazoles with broad substrate scope. The lead compound 5qq exhibited potent antimicrobial activity (MIC = 4 µg/mL) via DNA gyrase...

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Cite This Study

Krishna et al. (Wed,) studied this question.

synapsesocial.com/papers/69b79e6e8166e15b153abbe8 https://doi.org/https://doi.org/10.1039/d6ob00043f

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