Background: Pain remains a debilitating symptom for cancer patients, with over half of patients experiencing it during their illness. While pharmacological treatments are the primary approach, their limitations have prompted exploration of alternative methods, among them: non-invasive brain stimulation. Despite its safety, affordability, and growing evidence base, transcranial direct current stimulation remains underutilized in cancer care, and patient’s attitude toward its use is unknown. Methods: A cross-sectional survey was conducted at a single oncology center employing a mixed‑format questionnaire comprising single‑choice and multiple‑choice response options. It assessed the patients’ acceptance of pain therapies, and willingness to participate in clinical trials, with a focus on transcranial direct current stimulation as a pain management modality in oncology care. The study also examined associations between acceptance levels and factors such as pain presence, pain intensity and demographic characteristics. Results: Of the 179 oncology patients approached, 124 provided valid responses (usable response rate: 83.2%). In the study sample, the average age was 62 years, with a predominance of female participants. Colorectal and breast cancer were most common, and nearly half of the cohort had stage IV disease. Clinically significant pain (Numerical Rating Scale ≥ 4) was reported by 34.68% of patients, with a higher prevalence among those with metastatic disease (46.5% vs 24.2%, p = 0.009). Survey responses revealed polarized attitudes toward morphine, consistent acceptance of non-pharmacological treatments, and moderate support for transcranial direct current stimulation. Demographic, clinical, and pain-related variables did not significantly influence responses, nor the acceptance of tDCS. Conclusion: Gaining insight into patient perspectives on pain management is crucial for the effective integration of innovative, non-pharmacological approaches within supportive oncology care. The present study offers foundational data to guide subsequent research and inform strategies for clinical implementation. Keywords: chronic pain, cancer, trial acceptance, transcranial direct current stimulation, treatment acceptance
Chiriac et al. (Sun,) studied this question.