Preparation of self-microemulsifying drug delivery system for mixed volatile oil from italicJingu Zhitong Gel /italic（筋骨止痛凝胶）

Key Points

• This research aims to develop a stable self-microemulsifying drug delivery system for a mixed volatile oil from a Chinese medicine gel.
• Investigated compatibility of raw materials and emulsification appearance.
• Used pseudoternary phase diagrams for initial formulation screening.
• Employed D-optimal mixture design for formulation optimization based on particle size, PDI, and emulsification appearance.
• Conducted stability tests assessing various conditions such as centrifugation and dilution.
• The optimal formulation contained 56% volatile oil, 26% Tween 80, and 18% anhydrous ethanol.
• The resulting microemulsion was a pale yellow transparent solution with an average particle size of 105.06 nm and a PDI of 0.248.
• Zeta potential was measured at -7.98 mV, indicating good stability under various tested conditions.