5α-dihydrotestosterone upregulates interferon signaling and limits osteoclast differentiation during inflammatory state

Key Points

• This research aims to examine how 5α-dihydrotestosterone (DHT) affects interferon signaling and osteoclast differentiation in inflammatory conditions.
• Analyzed the impact of DHT on osteoclast precursor cells (OCPs)
• Assessed gene expression related to interferon processes in myeloid populations
• Investigated the differentiation trajectory of immune cells during treatment
• DHT treatment reduced the differentiation of OCPs into osteoclasts
• Differential expression of genes linked to interferon signaling was observed
• DHT influenced cellular pathways associated with osteoclastogenesis