Sphingosine 1‐Phosphate Receptor 1 and 5 Reciprocally Regulate IL ‐13 and IL ‐9 Production in Atopic Dermatitis

Key Points

• The research aims to explore how S1P signaling affects IL-13 and IL-9 production in atopic dermatitis.
• Examined S1P signaling pathways in relation to Th2 and Th9 cell responses.
• Analyzed the roles of S1PR1 and S1PR5 receptors in cytokine production.
• Investigated inflammation processes in atopic dermatitis.
• S1PR1 and S1PR5 were found to reciprocally regulate IL-13 and IL-9.
• Alterations in these cytokines were linked to Th2 and Th9-driven inflammation in atopic dermatitis.