Onychomycosis, a fungal infection of the nails, is a common dermatological condition that requires effective treatment. Conventional antifungal therapies often come with side effects, highlighting the need for safer, more natural alternatives. The objective of this study was to formulate and evaluate a herbal antifungal nail lacquer using Henna (Lawsonia inermis) and Neem (Azadirachta indica) leaf extracts as active ingredients, known for their potent antifungal properties. The herbal nail lacquer was formulated by incorporating Henna and Neem extracts into a nitrocellulose-based lacquer system. The lacquer was prepared using a combination of ethyl acetate as a solvent, castor oil as a plasticizer, glycerin as a humectant, and phenoxyethanol as a preservative. The formulation process involved blending the active ingredients with the film-forming agent, followed by thorough stirring and solvent evaporation to form a stable lacquer. The prepared formulation was evaluated for various physicochemical properties, including color, transparency, gloss, drying time, film thickness, water resistance, and adhesion properties. The antifungal efficacy of the lacquer was tested against common nail pathogen Aspergillus niger using standard antifungal tests. The results indicated that the herbal nail lacquer demonstrated excellent gloss and smooth flow, with a quick drying time and satisfactory film thickness. The antifungal activity was significant, with both Henna and Neem extracts showing promising results against fungal strains. Additionally, the lacquer exhibited good water resistance and adhesion, making it suitable for long-lasting application on nails. This study concludes that the formulated herbal antifungal nail lacquer using Henna and Neem extracts offers a safe, effective, and natural alternative for the treatment of onychomycosis, providing both therapeutic benefits and cosmetic appeal. The formulation holds potential for future development and use as a topical treatment for fungal nail infections.
Ms. Nivedhita K. Shaine*1, Mr. Febin Sheen2, Mr. Mathew Chacko3, Mr. Muhammad Shiyad M. P.4, Ms. Aneena Aliyar5, Mrs. Reshma B.6, Dr. Sabu M. C.7 (Mon,) studied this question.