Abstract Granuloma inguinale (donovanosis) is a chronic granulomatous infection caused by Klebsiella granulomatis, predominantly affecting sexually active adults in endemic regions. Pediatric cases are exceedingly rare and pose diagnostic challenges, particularly in non-endemic settings. We report an unusual case of granuloma inguinale in an 8-month-old male infant from Syria who presented with multiple painless ulcerative lesions involving the genital and diaper areas. Diagnosis was established through identification of Donovan bodies on Giemsa stain and confirmed by histopathological examination. The patient showed an excellent clinical response to oral azithromycin, with complete resolution of lesions and no recurrence during follow-up. This case highlights the importance of considering granuloma inguinale in the differential diagnosis of chronic genital ulcers in infants and underscores the need for careful safeguarding assessment and the role of histopathology in achieving an accurate diagnosis.
Hasan et al. (Sun,) studied this question.