The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming

Key Points

• Investigate how the MYBL2-GTSE1 axis influences the progression of laryngeal squamous cell carcinoma (LSCC) through specific molecular pathways.
• Examined the role of the MYBL2-GTSE1 axis in LSCC progression
• Analyzed PI3K/AKT signaling pathways
• Assessed metabolic changes related to glycolysis
• MYBL2-GTSE1 axis significantly enhances LSCC progression
• Inhibition of this axis affects PI3K/AKT-mediated metabolic reprogramming
• Suggests potential for developing targeted therapies against LSCC