What question did this study set out to answer?

To investigate the relationship between αS-SAA positivity and olfactory dysfunction in early Alzheimer's disease.

March 26, 2026Open Access

Alpha‐synuclein co‐pathology in a real‐world early Alzheimer's disease cohort

Key Points

To investigate the relationship between αS-SAA positivity and olfactory dysfunction in early Alzheimer's disease.
Analyzed αS-SAA positivity in an early Alzheimer's disease cohort.
Conducted longitudinal follow-up to assess symptom progression and potential treatment response.
Evaluated olfactory function in patients diagnosed with early Alzheimer's.
αS-SAA positivity was found to be common in the early stages of Alzheimer's disease.
A significant association was observed between αS-SAA positivity and olfactory dysfunction.
Further longitudinal studies are needed to determine if assay status can predict treatment responses.

Abstract

αS-SAA positivity is common in early AD and associated with olfactory dysfunction. Longitudinal follow-up is required to test if assay status predicts response to ATTs.

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Cite This Study

Shiner et al. (Sun,) studied this question.

synapsesocial.com/papers/69c4cd05fdc3bde448918cae https://doi.org/https://doi.org/10.1002/alz.71240

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