Methods: Records from the kidney transplant center were analyzed to document the attributes of eligible patients.One patient was chosen to take part in the study, with histological type categorized based on the HLA system.The degree of mismatch was assessed using the A-B-DR classification, while serum creatinine and NGAL levels were evaluated.Additional details, including age, sex, and the length of hemodialysis before transplantation, were likewise recorded.Results: The study revealed that NNGAL levels in patients correlated directly with the degree of mismatch .Higher sNGAL levels were observed with greater mismatch, particularly at the HLA-Dr level, while a lower sNGAL level was noted when incompatibility also occurred at the HLA-Dr level.Additionally, sNGAL levels showed a direct relationship with increasing serum creatinine.It was also found that sNGAL levels rose in conjunction with longer durations of hemodialysis before transplantation. Conclusion:In summary, NGAL and HLA typing are both vital in the context of kidney transplantation.NGAL serves as an important biomarker for kidney injury and graft function, while HLA typing is essential for ensuring immunological compatibility and minimizing rejection risks.Linking sNGAL levels with patients' existing HLA patterns could serve as an indicator for chronic rejection or early-stage renal damage.This approach could assist physicians in proactively managing the condition to minimize the risk of graft loss.Validation through larger, multicenter studies might strengthen these findings.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
ALANAN et al. (Wed,) studied this question.