Introduction: Background: Diabetic nephropathy is the leading cause of End Stage Renal Disease.Arginine Vasopressin (AVP) plays pivotal role in osmoregulation and renal water conservation.As diabetic patients are prone to develop renal complications, AVP system is considered as a novel target to be evaluated for possible disruption.Copeptin, a surrogate biomarker of AVP, is preferred over AVP due to comparatively stable structure and prolonged half-life.The study is designed to correlate the levels of copeptin among diabetes mellitus patients with worsening renal outcomes.Methods: It was a comparative cross-sectional study.Individuals were stratified into progressive deteriorating stages of nephropathy as per NKF KDOQI guidelines.Different biochemical variables HbA1c, serum BUN, serum creatinine UACR and GFR were got done from the affiliated lab.Serum copeptin levels were determined using Copeptin sandwich ELISA technique.Data was analyzed through Statistical Program for Social Sciences (SPSS).Results: Out of the 120 subjects, 30% of them (n = 36) developed severely decreased kidney function with GFR less than 30mL/min/ 1.73m2.Copeptin levels were seen to be progressively increased with stages of albuminuria (385.297288.36pg/ml at stage 3) with positive correlation i.e. r = 0.375, p = #0.001and negatively correlated with decline in GFR (291.73268.82pg/ml at stage 5) i.e. r = -0.409,p = #0.001.Conclusion: Significant association of copeptin with worsening of renal functions in DM implies the pivotal role of AVP system in osmoregulation and body homeostasis.Timely detection may eventually delay the progression of ESRD and its consequences.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Khan et al. (Wed,) studied this question.