Novel zerumbone-amide-triazole hybrids as potential NF-κB pathway inhibitors: design, synthesis, cytotoxicity evaluation, computational studies, and mechanistic insights

Key Points

• The study focuses on designing and synthesizing new zerumbone-amide-triazole hybrids to evaluate their potential as NF-κB pathway inhibitors.
• Designed and synthesized fifteen zerumbone-amide-triazole hybrids via Click reaction
• Evaluated cytotoxicity against various cancer cell lines
• Conducted computational studies to understand mechanism of action
• Certain hybrids exhibited significant cytotoxic effects on tested cancer cell lines
• Indication of effective inhibition of the NF-κB pathway
• Computational insights provided support for the proposed mechanisms