Development of Minoxidil-Loaded Calcium Citrate Nanoparticles

Key Points

• The central aim is to develop calcium citrate nanoparticles loaded with minoxidil to enhance its solubility and reduce irritation.
• Synthesis of calcium citrate nanoparticles using a precipitation method
• In vitro evaluation of minoxidil release from the nanoparticles
• Assessment of the nanoparticles' physical and chemical properties
• Minoxidil-loaded nanoparticles exhibit improved aqueous solubility
• Formulation demonstrates reduced irritation compared to standard minoxidil solutions
• In vitro tests show sustained release profiles for minoxidil from the nanoparticles