Ring-opening metathesis polymerization (ROMP) has grown from an extension of olefin metathesis into a powerful, modular platform for synthesizing precision macromolecules. In this review, we explore the evolution and current landscape of strain-driven ROMP, beginning with historical and mechanistic foundations. A central focus is placed on the concept of ring strain─its theoretical basis, thermodynamic consequences, and practical implications for polymerizability. We critically examine the roles of ΔH, ΔS, and computational tools in guiding monomer selection and design, with tabulated comparisons across key monomer classes including cyclopropenes, cyclobutenes, cyclopentenes, larger rings, and bridged-ring systems. This review aims to bridge foundational understanding with new opportunities, guiding both experienced practitioners and newcomers in advancing the frontiers of ROMP.
Elling et al. (Thu,) studied this question.
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